基因表达谱大数据在抗癌药物研发中的应用

刘阳; 白卉; 伯晓晨

doi:10.11959/j.issn.2096-0271.2016051

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基因表达谱大数据在抗癌药物研发中的应用

研究 | 更新时间：2024-06-03

- 基因表达谱大数据在抗癌药物研发中的应用
- Application of large scale gene expression profiles in anticancer drug development
- 大数据 2016年2卷第5期页码：2016051
- 作者机构：
- 作者简介：
  
  [ "刘阳（1988-），男，军事医学科学院放射与辐射医学研究所博士生，主要研究方向为生物医学大数据挖掘。" ]
  [ "白卉（1982-），女，军事医学科学院放射与辐射医学研究所博士后，第四军医大学药理学博士，主要研究方向为反义抗菌核酸药物和网络药理学。先后承担各类国家和军队科研项目10余项，发表SCI期刊论文10篇，参编英文专业书稿3部，现为中国药理学会会员。" ]
  [ "伯晓晨（1973-），男，军事医学科学院放射与辐射医学研究所研究员、博士生导师，主要研究方向为生物医学大数据处理与挖掘技术。先后承担各类国家和军队科研项目20余项，发表SCI 期刊论文50篇。现兼任北京自动化学会理事、中国药理学会网络药理学专业委员会常务委员、军队转化医学委员会委员、中国生化与分子生物学会青年委员。" ]
- 基金信息：
  
  国家自然科学基金资助项目;The National Natural Science Foundation of China(U1435222)
- DOI：10.11959/j.issn.2096-0271.2016051
  中图分类号： Q811.4，R9
- 网络首发：2016-09，
  
  纸质出版：2016-09-20
- 稿件说明：
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刘阳, 白卉, 伯晓晨. 基因表达谱大数据在抗癌药物研发中的应用[J]. 大数据, 2016,2(5):2016051.

Yang LIU, Hui BAI, Xiaochen BO. Application of large scale gene expression profiles in anticancer drug development[J]. Big data research, 2016, 2(5): 2016051.
刘阳, 白卉, 伯晓晨. 基因表达谱大数据在抗癌药物研发中的应用[J]. 大数据, 2016,2(5):2016051. DOI： 10.11959/j.issn.2096-0271.2016051.

Yang LIU, Hui BAI, Xiaochen BO. Application of large scale gene expression profiles in anticancer drug development[J]. Big data research, 2016, 2(5): 2016051. DOI： 10.11959/j.issn.2096-0271.2016051.

摘要

作为功能基因组学中重要的组成部分，基因表达谱在生物学、医学和药物研发等多个领域发挥着重要作用。特别是随着精准医疗概念的提出，整合包括基因表达谱在内的多组学数据用于个性化医疗是未来的发展趋势。从抗癌药物研发背景出发，介绍了基于细胞扰动表达谱的大数据分析方法，并且总结了其在抗癌药物研发中的应用。

Abstract

As an important part of functional genomics

gene expression profile plays an important role in many fields

such as biology

medicine and drug discovery.With the advent of precision medicine

integration of multi-omics data including gene expression profile data for personalized health care is becoming the trend of future medicine.The advances of anticancer drug development were introduced firstly

and then the methods for perturbational gene expression profile analysis were illustrated

especially connectivity map idea.Finally applications of these data in anticancer drug development were summarized.

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references

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